Seminar aus Informatik (2SE)
| LVA-Nr.: | 365.013 |
| LVA-Leitung: | Werner Retschitzegger (Topic 1) Sepp Hochreiter (Topic 2) Ulrich Bodenhofer |
| Vorbesprechung: | Werner Retschitzegger (Topic 1): Fr 10.10.2008, 12:00-13:30, T642 Sepp Hochreiter (Topic 2): tba |
| Typ: | SE, 2h, Block |
| Anmeldung: | KUSSS |
Topic 1: Model Transformations - The Critical Success Factor of Model-Driven Engineering (Retschitzegger)
The paradigm shift in engineering from a code-centric to a model-centric view emerged not least due to the standardization of the Unified Modelling Language (UML) in 1997, and the advent of the latest considerably reworked version in 2005, after years of the so-called 'method wars' in the early 90ies. With this, the prescriptive nature of models is augmented with an additional constructive role. This means that models are no longer used just as a sketch to communicate ideas or to explore alternatives, nor serve as specifications for programmers who have then to manually implement the system, but are treated as programs themselves. With this new paradigm called 'Model-Driven Engineering' (MDE), models specify the whole system at different levels of abstractions whereby systematic transformations are employed for a step-wise code generation. The availability of model transformation languages is not only an essential prerequisite to exploit the constructive nature of models in terms of vertical transformations, thereby changing the level of abstraction and building the bases for code generation, but also to allow horizontal transformation of models that are at the same level of abstraction. Horizontal transformations are of specific interest to realize different integration scenarios such as model translation (e.g. translating an ER model into a UML class model), model augmentation (e.g., weaving aspects into a UML class model), or model alignment (e.g., mapping a content model to its GUI view).Ziel dieses Seminars ist es, in Form von Gruppenarbeiten einen Überblick über die spezifischen Probleme der Transformation von Modellen im Bereich MDE zu geben. Es sollen von den unterschiedlichen Gruppen interessante Ansätze in diesem Gebiet vorgestellt werden und insbesondere auch neue Entwicklungen und offene Forschungsthemen behandelt werden. Basisliteratur:
- Portal Site: http://www.model-transformation.org
- Czarnecki, K, and Helsen, S : Classification of Model Transformation Approaches.
In: Proceedings of the OOPSLA'03 Workshop on the Generative Techniques in the Context
Of Model-Driven Architecture, Anaheim, California, USA.
http://www.swen.uwaterloo.ca/~kczarnec/ECE750T7/czarnecki_helsen.pdf - Object Management Group (OMG). 'MOF QVT Final Adopted Specification'. ptc/05-11-01, March 31, 2007
http://www.omg.org/docs/ptc/05-11-01.pdf
Topic 2: Analyzing data from microarrays and next generation sequencing (Hochreiter)
Life sciences will dominate the 21st century: As soon as we understand the complex functional network of the cell we can develop cures for most diseases. We are still far from a complete understanding of this network, but bioinformatics is undoubtedly the key technology to get there. Bioinformatics played an integral role in one of mankind's most notable advances - the complete sequencing of the human genome. However, we are just at the beginning of deciphering life because the genomic sequence alone tells us nothing about structure or function. The mechanisms that control gene activation, its scale and timing are not well understood.One of the primary tasks in bioinformatics is to help analyze genomic data. Bioinformatics approaches are also needed to interpret, analyse, compare, manage and simulate data collected by molecular biological measurement techniques. Currently the most prominent measurement techniques are microarrays and sequencing not only of the DNA but also of the activated genes (the RNA). One of the long-term objectives in bioinformatics is to replace molecular biological experiments by simulations and predictions made in silico as this would mean immense cost savings and accelerate the development of novel nanotechnologies and drugs. General topics:
- Microarray technology for expression: identifying genes relevant for cancer
- Microarray technology for genotyping: identifying copy number variations and single nucleotide polymorphisms associated with diseases
- Next generation sequencing: structural variants of the DNA, transcriptome
- In this seminar actual literature have to be analyzed, interpreted, and reflected by a talk and eventually by a written document
- Specific topics and literature will be given in the first meeting