Special Topics on Bioinformatics: Population genetics (2KV)
| Course no.: | 365.036 |
| Lecturer: | Günter Klambauer |
| Times/locations: | until Thur March 31, 10:15-11:45, room T211 from Apr 5 on Tues, 12:00-13:30, room K224B additionally Tue May 10, May 24, Jun 02, 13:45-15:15, room K223B |
| Start: | Thur March 10, 2011 |
| Mode: | KV, 2h, weekly |
| Registration: | KUSSS |
Motivation:
Population genetics is the field of study that finally brought together Darwin's and Mendel's ideas and built the basis of modern evolutionary synthesis. The focus is on the distribution and the changes of distribution of genes in populations. Population genetics constructs mathematical models of evolution, studies their behavior and checks whether the states of populations are compatible with this behavior. Recently new molecular methods of detecting polymorphisms have brought dramatic changes to this field. Basic mathematical knowledge is necessary for this course. It will start with a biological introduction and will then present models for mutation, selection and genetic drift. All theoretical concepts will be supported with real biological examples and data. In addition we will elaborate exercises that range from simple calculations to complex mathematical proofs.Topics:
- Biological basics and methods
- The Hardy Weinberg Law
- Random genetic drift
- Selection
- Mutation
- Inbreeding and other effects
- Human population genetics