Special Topics on Bioinformatics: Population genetics (2KV)
| Course no.: | 365.036 |
| Lecturer: | Günter Klambauer |
| Times/locations: | Thur 10:15-11:45, room KG 712 |
| Start: | Thur March 4, 2010 |
| Mode: | KV, 2h, weekly |
| Registration: | KUSSS |
Motivation:
Population genetics is the field of study that finally brougth together Darwin's and Mendel's ideas and built the basis of modern evolutionary synthesis. The focus is on the disribution and the changes of distribution of genes in populations. Population genetics constructs mathematical models of evolution, studies their behaviour and checks whether the states of populations are compatible with this behaviour. Recently new molecular methods, that detect polymorphisms, have brougth dramatic changes to this field. Basic mathematical knowledge is necessary for this course. It will start with a biological introduction and will introduce models for mutation, selection and genetic drift. All theoretical concepts will be supported with real biological examples and data. Furthermore additional exercises, that range from simple calculation to complex mathematical proofs, will be presented.Topics:
- Biological basics and methods
- The Hardy Weinberg Law
- Random genetic drift
- Selection
- Mutation
- Inbreeding and other effects
- Human population genetics